Posted by SLS on April 13, 2001, at 10:36:37
In reply to Richelson-GABA antagonists, posted by PaulB on April 12, 2001, at 17:56:16
> Because the benzodiazepines are unselective for GABA receptors and stimulate gabergic receptors involved in reducing anxiety and panic as well as those receptors involved in sedation I was wondering whether benzodiazepines could be augmented with selective GABA antagonists to allow a person to continue to experience the anxiolytic effect of the drug but eliminate the amnesic and sedative effects that the benzodiazepines have? Can you mention any that are available?
I think I heard something about the designing of benzodiazepines to be selective for, or specific to, one of the several *benzodiazepine* receptors. Supposedly, the result is a drug that retains its anxiolytic properties without producing tolerance or sedation. I don’t remember the details very well.
- Scott
poster:SLS
thread:59594
URL: http://www.dr-bob.org/babble/20010411/msgs/59673.html