Posted by Cam W. on April 16, 2001, at 20:29:50
Dr.Richelson - I noticed that in your slide of alpha-1 adrenergic receptor binding that Effexor had no binding potential. I have seen clinically and have read in some articles and reviews that a small portion of patients (esp. those one doses of more than 300mg qd) do have significant increases in blood pressure. I have noticed that a few of these have been transient (ie disappear within a week), while others have been sustained, requiring a dosage decrease or, more commonly, a switch to another antidepressant.
Could you please comment on a proposed mechanism of action for this blood pressure increase. Could the lack of alpha-adrenergic antagonism be a clinical difference in what we see in vitro (or in animal models), with what occurs in humans in vivo (ie actual antagonism of alpha-adrenergic receptors in some people in vivo).
Thanks for your time - Cam W.
poster:Cam W.
thread:60116
URL: http://www.dr-bob.org/babble/20010411/msgs/60116.html