Posted by SLS on April 22, 2001, at 13:24:56
In reply to Geodon and nausea, anyone?, posted by anita on April 22, 2001, at 9:10:22
> Hiya,
>
> I took just one 20mg dose of Geodon and had terrible nausea, as well as a runny nose and tearing eyes. I even dreamt I was vomiting. I'm going to try dissolving the powder in water and take half the dose, I guess. Do you know if this side effect tends to go away over time? I had high hopes for this med and am really distressed that I can't seem to tolerate it.
>
> thanks,
> anita
Hi Anita.I am VERY disappointed for you. I don't understand the runny nose and tearing eyes yet. Maybe the nausea and these other things are the result of the significant antagonism of 5-HT1D receptors that ziprasidone demonstrates. Do you also have a headache? I guess you'll have to wait for some feedback to see if these are transient start-up side effects. I'm sure you know that nausea is consistently listed in clinical studies to be one of the three most frequent adverse effects. I doubt you will want to go this far, but you might be able to mitigate these side effects by using sumatriptan, a 5-HT1D agonist. Perhaps ondansetron, a 5-HT3 antagonist, would be useful. I wonder if the nausea is more prominent at very low dosages, including the beginning of a titration to a higher dosage. D2 presynaptic autoreceptor antagonism? Probably a silly thought.
Sorry. I doubt that anything I wrote is of any practical use. More heuristic, I guess.
Short rant:I am wondering just what exactly is going on with this NE and 5-HT reuptake inhibition stuff with ziprasidone. I can't find anything except for the following often-cited study. I believe it was an 'in vitro' experiment using synaptosomes at possibly irrelevant high concentrations. I would like to see some cooraborative data before considering reuptake inhibition to be a putative functional 'in vivo' property of ziprasidone. What does Dr. Stahl use as his sources of information regarding this?
I hope things work out with ziprasidone. You deserve a break.
- Scott
-------------------------------------------------------------------Seeger TF, et al. Ziprasidone (CP-88,059): A new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther 1995;275:101-113
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poster:SLS
thread:60754
URL: http://www.dr-bob.org/babble/20010417/msgs/60761.html