Posted by KS on April 24, 2001, at 14:52:20
In reply to Re: Matze, Neal- selegiline for depression, posted by AndrewB on April 23, 2001, at 1:03:26
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> Can low doses of selegiline (2.5 to 5mg.) improve mood. Yes and no. By itself selegiline is not effective against depression. Similarly, by itself the nutritional supplement L-phenylalanine is not effective against depression. However when combined together, there is significant evidence that they can be very effective in treating depression, especially dysthymia. L-phenylalanine (and D-phenylalanine) is metabolized into PEA, a natural compound in the body, with an amphetamine like structure, that is proposed to enhance mood and energy. PEA however is quickly broken down in the body into another substance by MAO-B. Therefore, an MAO-B inhibitor, namely selegiline, is required for phenylalanine supplements to be effective in raising the body’s level of PEA. Unlike manmade amphetamines, PEA’s mood enhancing and energizing effect does not diminish over time. The most common side effect of phenylalanine supplementation probably is a sense of inner tension. Again, it is my best guess, that cocommitment use of amisulpride lessens or eliminates the likelihood of such a side effect.
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> In sum, if you are taking low dose selegiline, you may well benefit by l-phenylalanine or d-l-phenylalanine supplementation. Dosage would be approximately 1,500mg. to 6,000mg./day, taken three times a day. For example, 1,000mg. in the morning, 1,000 at noon, the last 1,000mg. in the afternoon. Take at least 30 minutes before a meal.
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THANKS FOR THE ABOVE INFO ...It's not the first time I've seen this combo (i.e., selegiline plus DLPA) advocated. Has anyone tried it? I'm quite to do so, but would prefer more input from you guys.
Cheers, KS
poster:KS
thread:60583
URL: http://www.dr-bob.org/babble/20010424/msgs/61022.html