Posted by SalArmy4me on May 30, 2001, at 4:27:58
In reply to Re: Drug-induced Sexual Dysfunction Augmentation, posted by Thrud on May 30, 2001, at 2:00:13
From . Landen, Mikael MD et al. Effect of Buspirone on Sexual Dysfunction in Depressed Patients Treated With Selective Serotonin Reuptake Inhibitors. Journal of Clinical Psychopharmacology. 19(3):268-271, June 1999:
"Basically, we're talking about buspirone fighting sexual dysfunction in SSRI's. The mechanism of action in this is not obvious. Selective alpha2 receptor antagonists facilitate sexual behavior in animals; moreover, the alpha2 receptor antagonists yohimbine and mianserin have been reported to reduce SSRI-induced sexual dysfunction in man. Thus, the assumption that the effect of buspirone on sexual function is a result of the alpha2 receptor antagonism exerted by the buspirone metabolite 1-(2-pyrimidyl) piperazine dihydrochloride is not far-fetched. However, given the profound influence of 5-HT1A receptors on sexual activity in rodents, the possibility that the partial agonism exerted by buspirone vis-a-vis this receptor subtype is also of importance in this context and cannot be excluded.
Menkes, D. B.. Buspirone Augmentation of Sertraline. British Journal of Psychiatry. 166(6):823-824, June 1995.
This case-study claims the use of 60-90 mg of buspirone is needed for adequate treatment of depression.
poster:SalArmy4me
thread:64693
URL: http://www.dr-bob.org/babble/20010530/msgs/64701.html