Posted by SalArmy4me on May 31, 2001, at 7:02:48
In reply to Testosterone injections for low sex drive in women, posted by netsurferchick on May 30, 2001, at 20:36:36
Shifren, Jan L. et al. Transdermal Testosterone Treatment in Women with Impaired Sexual Function. New England Journal of Medicine. 343(10):682-688, Sept 7, 2000:
"In regard to psychological status, testosterone replacement had a beneficial effect on well-being and depressed mood. The differences in the scores on the Psychological General Well-Being Index between the placebo and testosterone periods in our study are similar to the differences in scores between women who received estrogen alone...
Finally, transdermal testosterone was not associated with clinically important changes in acne, hirsutism, or laboratory-test results, nor did it negate the beneficial effects of oral estrogen-replacement therapy on hot flashes and serum concentrations of high-density lipoprotein cholesterol."
Dosage and Administration Notes:
"Of the available oral preparations, methyltestosterone in combination with esterified estrogen (EE; either 0.625 mg EE plus 1.25 mg methyltestosterone or 1.25 mg EE plus 2.5 mg methyltestosterone) has been the most studied and in the currently available doses in North America offers therapeutic benefits, but has occasional side-effects. Although long term therapy with large doses of this compound has adverse hepatic effects, this has not been seen with lower doses (41). This oral therapy does, however, negate some of the beneficial lipid effects of estrogen, with reductions in high density lipoprotein cholesterol and apolipoprotein A1 with 0.625 mg EE plus 1.25 mg methyltestosterone (41). This combined therapy does not appear to attenuate the favorable effects of EE on vascular reactivity (42) and is associated with reduced concentrations of apolipoprotein B (41, 43) and increased total body low density lipoprotein cholesterol catabolism (43). Physicians should be aware that androgenic side-effects may occur with the EE/methyltestosterone preparations (41) and should warn patients of this possibility and monitor for androgenic side-effects. As this compound cannot be measured in serum in a clinical setting, it is impossible to recommend biochemical treatment guidelines."
poster:SalArmy4me
thread:64802
URL: http://www.dr-bob.org/babble/20010530/msgs/64848.html