Posted by SalArmy4me on June 1, 2001, at 10:38:10
In reply to Effexor Xr and liver function????????????????, posted by DebbieLynn on June 1, 2001, at 10:06:31
The possibility of liver disease caused by venlafaxine alone is still rare, despite the many insufficient case-studies that implicate venlafaxine in every illness since the Great Plague.
Kent, Justine M. SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression. Lancet. 355(9207):911-918, March 11, 2000.
Because of mirtazapine's unique pharmacology, antihistaminergic effects predominate at lower doses (drowsiness, sedation), whilst noradrenergic neurotransmission increases with increasing doses, counteracting some of the antihistaminergic effects. Therefore, to avoid excessive sedation, doses below 15 mg are not recommended. Clearance of mirtazapine is reduced in patients with liver (up to 30%) or kidney (30-50%) disease, and in the elderly. Dose reductions should be considered in these populations.
Horsmans, Yves MD. De Clercq, Michel MD. Sempoux, Christine MD. Venlaxafine-Associated Hepatitis. Annals of Internal Medicine. 130(11):944, June 1, 1999.
"We believe that there was a causal association between venlafaxine and hepatitis because the histologic findings supported drug-related hepatotoxicity, other causes of hepatitis were excluded, discontinuation of venlafaxine therapy led to recovery, and venlafaxine can increase liver aminotransferase levels. Liver function test results should therefore be regularly monitored in patients receiving venlafaxine."
poster:SalArmy4me
thread:65012
URL: http://www.dr-bob.org/babble/20010530/msgs/65021.html