Posted by SalArmy4me on June 18, 2001, at 18:43:42
In reply to Has any one taken effexor with tramadol (ultram), posted by Victor on June 18, 2001, at 17:22:06
Ultram has a major interaction with Effexor:
The coadministration of serotonin reuptake inhibitors and other agents with serotonergic activity, including tramadol, may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors. Patients receiving this combination of drugs may also experience an increased risk of seizures. In general, the concomitant use of serotonin reuptake inhibitors and tramadol should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
--from CVS Drug Checker
poster:SalArmy4me
thread:66995
URL: http://www.dr-bob.org/babble/20010618/msgs/67002.html