Posted by AMenz on June 27, 2001, at 10:36:55
In reply to Re: stjames » AMenz, posted by Cam W. on June 25, 2001, at 10:30:18
Wouldn't the additional production of serotonin because of the lack of reuptake account for hypomanic or mixed state episodes of BPII's on SSRI's and other AD's?
Thanx for reply.
> AM - Here is a good, basic article on the HPA axis role in depression. Keep in mind that several other of the body's systems also interact wiith the HPA axis in modfying mood. As you read the following article, keep in mind this is only one set of chemical reactions and it is linked to several other systems. If you change one component of one system, all of the other systems all respond to this change. We haven't figured out all of the systems that come into play, let alone the ways that these systems can impact on the body's stress system.
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> http://www.sciam.com/1998/0698issue/0698nemeroff.html
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> The body doesn't stop producing the serotonin and norepinephrine on a global, bodily scale, but may decrease amounts locally in the body (ie blocking the axon terminal reuptake receptor, may slow down serotonin release from that particular axon - through the 5-HT1B receptor - but other receptors for serotonin are only altered indirectly or not at all).
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> I used to say (and still do in some presentations) that the lack of reuptake of a neurotransmitter would fool the body into making more of the neurotransmitter. This may happen, but I am not sure if it has been proven, especially when taken in the context of all of the other physiological systems involved in such a change.
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> Also, type "HPA axis" into the serach function and you can read some of the developments on our understanding of depression over the last few years.
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> - Cam
poster:AMenz
thread:67698
URL: http://www.dr-bob.org/babble/20010625/msgs/68068.html