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Re: Adrafinil (sort of) + Serzone » Sunny

Posted by Rick on June 30, 2001, at 0:58:32

In reply to Re: Amisulpride study, posted by Sunny on June 27, 2001, at 11:38:26

FWIW, I've been taking Serzone -- all in the daytime -- with 100 mg of modafinil, and they really seem to go together well. As you probably know, modafinil (brand Provigil/Alertec in U.S./Canada) is the primary metabolite of adrafinil and thought to provide most of the theraputic value. The combo really seems to balance out side effects (e.g., P fights S sedation and S keeps any P agitation at bay), while the *theraputic* effects are nicely synergystic.

I added the Provigil initially to counter Serzone fatigue, but the combo clicked so well (as long as I don't exceed 100mg Provigil too often) that I stayed with it. There are possible interactions between the two meds mediated by the CYP450 enzyme system, so monitoring is advisable. (Heck, monitoring advisable if you're taking just about *anything* with Serzone, including non-psychotropics.) ESPECIALLY with adrafinil -- which requires quarterly liver function tests -- you'd better be cautious. (I'm not sure how adrafinil is metabolized.)

Rick

> I'm wondering about any adverse reactions between adrafinil & serzone. Has anyone tried the combo?
> I'm hoping the adrafinil will help with serzone sedation.
> Thanks,
> Sunny
>
> > Thanks again...
> >
> > And I'll be able to contribute to your Amisulpride study pretty soon. I've been at 50 mgs. for three weeks, but I'm still pulling the Celexa out of the mix. I'll know more in a couple of weeks.


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