Posted by SalArmy4me on July 4, 2001, at 20:04:28
In reply to ADs and seizures, posted by Joe Schmoe on July 4, 2001, at 19:53:52
Oke, A.. Adhiyaman, V.. Aziz, K.. Ross, A.. Dose-dependent seizure activity associated with fluoxetine therapy. QJM. 94(2):113-114, Feb 2001:
"...Antidepressants may display both convulsant and anti-convulsant properties, and the most important determining factor is drug dosage.4 Mostly seizure associated with antidepressant therapy is seen after an acute overdose. Dose-dependent seizure activity has been well recognized with imipramine, amitriptyline, clomipramine and maprotiline. Less commonly, seizures can occur at therapeutic doses and there are two case reports of seizure associated with fluoxetine at a dose of 20 mg.5,6
Apart from the dose, duration of the treatment is also thought to be an important factor in assessing the risk of seizures. Life-table analysis has been used to estimate the cumulative risk of seizure activity for drugs such as clomipramine (data on file, Ciba-Geigy) and bupropion.7 Whether such a risk exists for SSRIs is not known. Other predisposing factors for the development of seizures are family history, underlying neurological problems, concurrent medications, substance abuse and rapid increments in the dose.3 With the exception of overdose, seizures associated with antidepressants are likely to occur during the first few weeks of treatment or after an increase in dose, as in our case..."
poster:SalArmy4me
thread:68976
URL: http://www.dr-bob.org/babble/20010701/msgs/68978.html