Posted by MB on July 17, 2001, at 2:12:39
In reply to Meridia stuff » MB, posted by Elizabeth on July 16, 2001, at 18:31:45
> > > Sibutramine is very long-acting -- you'd only have to take it once a day.
> >
> > Hmmm...I wonder what he was talking about, then.
>
> Hmmm back atcha. < g >Shall we just hummm a tune... ;-)
> I'm looking at the PI, and it seems that I was wrong about the elimination half-life (it's only an hour or so). It might be that (like other diet pills) it mainly works in the first few weeks (at most) so steady-state levels aren't an issue. The recommended dosing schedule is once daily.
>
> > Have you had a chance to watch that video about the metabolic effects of atypical antidepressants?
>
> Which video? Did I miss something?Try this link:
http://www.mentalhealth.ucla.edu/cgi-bin/av-npi?gr010123jmB
or go here and scroll down to "Metabolic Effects of Atypical Antipsychotics"
http://www.mentalhealth.ucla.edu/opce/gr.html
I thought it was really interesting
> > The way the commercial goes: "...people who abuse Meridia may become dependent," I thought this stuff was like an amphetamine or something. Why do you think they're treating it like this?
>
> My guess: because it's marketed as a diet pill and because some of the preclinical trials showed signs of abuse potential in animal models. There are always some false positives in those models, though.If I were a rat, I'd hit the damned lever too!! Oh, wait, I *am* a rat...but not that kind...
> > I think some people can actually *lose* weight on Moban!
>
> If only in virtue of having gotten off of other antipsychotic drugs.
>
> Moban did something totally weird to me when I tried it. I wasn't asleep (I was taking it for insomnia), but I was totally immobilised. Not comfortable!Thorazine did that to me. I was young and dumb and thought it could be taken recreationally...one of my dumber moments. I could move my eyes around, but couldn't move my body. Very un-fun.
> > Negative symptoms...like flat affect, etc?
>
> Yes.
>
> > It will be interesting to see what the outcome of the drug's use is in the long term. I remember when there was discussion in the late eighties (and early nineties) about using SSRIs as diet drugs...whoops!
>
> I think that "d'oh!" is the appropriate expression here.
>
> > No, of course not...but can it be figured out? If the brain were simple enough to be figured out, would the mind of such a brain be intellegent enough to do the figuring? Did that make any sense? wait...huh...? ;-P
>
> That's a claim that has been made by some: that we can't use our own consciousness to understand that consciousness. (I don't buy it, of course.)How close do you think we are now? It seems like so many advances have been made in the past decade alone.
> > I think treatment plans need to be highly individualized
>
> That's true. Everybody's different. (I don't think this is unique to psychiatry.)
>
> > > Yeah. You know, migraine has pretty much been redefined as any headache that responds to sumatriptan!
> >
> > That's kinda funny...but if it works and helps people get well...why not use that definition?
>
> That's mostly my general feeling, too.
>
> -elizabeth
poster:MB
thread:59947
URL: http://www.dr-bob.org/babble/20010714/msgs/70446.html