Posted by jojo on August 2, 2001, at 13:42:25
In reply to Re: Buprenorphine Question » jojo, posted by Elizabeth on August 1, 2001, at 14:14:06
> > 0.1 cc out of 1.0 is still only 10%, and since I don't feel its effects or affects
> > (must be that injection of Xylocaine I take beforehand ; >) ... ). I'm sitting up, of
> > course. How else does one use a "spray" bottle, you silly goose!
>
> Well, that might be why it's not working; try lying down with your neck hyperextended, and stay in that position for a couple of minutes after taking the buprenorphine. Afrin is a locally-acting drug; buprenorpine is not.
>
> (BTW: I'll cop to silly, but I'm no goose.)
>
> > Unless I just haven't crashed yet (I shudder at the thought), it appears to be a very
> > effective "antidepressant", and after one month, the only "side effects" seem to be a
> > little constipation during the first few days.
>
> That makes me think even more that it's not getting absorbed.
>
> > As this is REALLY off label, and there have only been a few publications, how do we
> > know that 12 mg. per day is the appropriate dose. Your impression is that one feels
> > the effect in an hour or so. I can always take another hit.
>
> 12 mg? That's an awful lot -- like, 40 mL, a volume that is ill-suited for intranasal (or IM) administration, even if you're taking it in many divided doses. Are you really taking it every 2 hours? Do you sleep???
>
> BTW, it might work faster (than 1 hour after each dose, that is) if you reach steady state. I probably don't have much of a steady-state concentration because I can't take it at bedtime (too activating).
>
> -elizabethI'm sorry. Of course it's 1.2 mg., not 12 mg.
"Well, that might be why it's not working; try lying down with
your neck hyperextended, and stay in that position for a couple
of minutes after taking the buprenorphine. Afrin is a
locally-acting drug; buprenorpine is not."Of course, when I used the drops from the syringe (after removing the needle) I lay
down with my neck hyperextended, and of course it was an empty
Afrin metered sprayer before I washed it and added the buprenorphine.
I was following your suggestion to use a metered sprayer. Even though Afrin works
locally and buprenorphine does not, both are absorbed via the mucus membrane.
Why do you insist that it's not working? Because I'm not aware of any affects
or effects other than the early constipation? I think that indicates that it IS working.
Actually, I think it's working very well. An antidepressant that prevents or induces
recovery from depression without one feeling any ill or "side effects" seems to be the ideal drug.jojo
poster:jojo
thread:72061
URL: http://www.dr-bob.org/babble/20010731/msgs/73122.html