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Re: Mixing Wellbutrin and SSRIs: Seizure risk?

Posted by djmmm on August 2, 2001, at 18:53:18

In reply to Mixing Wellbutrin and SSRIs: Seizure risk?, posted by Joe Schmoe on August 2, 2001, at 8:15:28

> I notice there is a trend to add Wellbutrin to SSRIs to combat sexual side effects. However, when reading the Wellbutrin literature, it says its seizure risk is increased when mixed with other medications which lower the seizure threshold, "such as other antidepressants."
>
> Is it safe to mix Wellbutrin and SSRIs?
>
> I am taking Wellbutrin right now but I know someone else who is taking Wellbutrin SR 150/day (low dose) and her doc added Celexa "for the serotonin effects." Not sure what that means in terms of results - what will Celexa deliver that the Wellbutrin will not? But in any case I was wondering if it was safe.

The seizures associated with Wellbutrin occured in a sample group while the drug Bupropion HCL was being tested as an appetite suppressant....the sample group consisted of primarily *Bulimic women* who, as everyone knows, are several times more prone to seizures than the average "healthy" adult.

The truth is, Wellbutrin has a seizure risk no greater than that of any other antidepressant...

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3134343&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1744061&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6406457&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6406456&dopt=Abstract


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URL: http://www.dr-bob.org/babble/20010731/msgs/73160.html