Posted by SalArmy4me on August 9, 2001, at 8:58:25
In reply to skin discolouration on paxil??, posted by AVR on August 9, 2001, at 4:41:41
Paxil has a rash as an uncommon side-effect; nowhere did I find that Paxil was discontinued because of a rash in clinical trials...
MARGOLESE, HOWARD C. M.D. Cutaneous Vasculitis Induced by Paroxetine. American Journal of Psychiatry. 158(3):497, March 2001.
"...Other dermatologic adverse effects, including pruritus, rash (mainly urticarial), and ecchymosis, among others, have been reported with paroxetine (4). However, to our knowledge, this is the first report of cutaneous vasculitis induced by paroxetine. The reemergence of the problem during another trial with the drug strongly supports the association between the two. Paroxetine's high-affinity binding to human platelet membranes (5) and serotonin's ability to induce and augment platelet aggregation (6) may explain this reaction. Physicians should be alert to this potential serious complication with antidepressant medications, including paroxetine..."
Mir, Shameem. Taylor, David. The adverse effects of antidepressants. Current Opinion in Psychiatry. 10(2):88-94, March 1997:
"Rare adverse effects such as rash (especially with fluoxetine) and hair loss [23,24] have been reported..."
poster:SalArmy4me
thread:74292
URL: http://www.dr-bob.org/babble/20010809/msgs/74307.html