Posted by kregpark@yahoo.com on September 3, 2001, at 2:43:13
In reply to Re:SP Cocktail/Mechanisms of Action/Memory Culprit » PaulB, posted by Rick on August 28, 2001, at 20:37:13
On dopamine: (Finally Bill I *think* I might disagree with you on something here !! :)
> Outside of PB I have yet to come across evidence or opinion that medicines that enhance dopamine are helpful for SP. There was one example though, in reference to Parnate, whose added 'noradrenergic and dopaminergic effects' make it superior to Nardil for SP. I know people will disagree here because there is no question that Nardil has similar effect and Nardil is often considered superior to Parnate?
>I believe that in many moderate to severe cases of SP dopamine plays a role:
Studies:
Nardil boosts serotonin and dopamine (granted dopamine to a lesser extent).
Klonopin tends to "stablize dopamine levels" as it is often used as a 2nd liner for bipolar swings.
Klonopin tends to induce depression with antiserotonin effects, possibly suggestive of enhanced dopamine function in certain brain regions (Davidson - 1992?)
2 studies show low D2 function in social phobics.Personal experiences:
*Good drugs for me at least short term*
1) On acute basis, Dexedrine very prosocial. (never tried chrnoically)
2) On actue short term Ritalin very prosocial (less than dexedrine, far shorter lasting prosocial effect, no 5ht increase).
3) *Amineptine* *very* prosocial and prosexual on acute basis (where it acts primarily as selective D2 dopamine enhancer), unfortunately becomes large noradrengeric in chronic use.
4) Nardil of course
5) Parnate when add low dose Xanax.
6) Eldepryl low dose with Remeron and add low dose Xanax.
7) PROVIGIL GOOD ANYTIME ALL THE TIME !!!*Not so good dopaminergics for me:*
1) amantadine - reduction of Nardil benefit (but proenergy, prosexual)
2) mirapex (pramipexole) - depressive somewhat - is d3 selective which is not a good predictor of success based on research )* in between *
1)Wellbutrin (depends what I took it with)
With Xanax or tramadol very effective.
With SSRI's not effective (anti-sp)
With Nardil in low dose *EFFECTIVE* - MUCH LIKE PROVIGIL IF DOSE LOW.have been prosocial in my case.
Also amineptine *very* prosocial prosexual on acute basis (where it primary action is very selective dopamine enhancement)
Unfortunetly on chronic basis amineptine becomes much more noradrenergic.
poster:kregpark@yahoo.com
thread:36517
URL: http://www.dr-bob.org/babble/20010902/msgs/77501.html