Posted by mgrueni on September 7, 2001, at 5:46:18
Uhm, first let me say that I don`t mean to be impolite by directly asking a particular poster. Of course I would appreciate everyone`s explanation. It´s just that I thought this special question would be best adressed to you (as you are a pharmacist), Cam.
I am a pharmacist assistant, so I do know the basics about how antidepressants work.
My question is about Effexor.
I fully understand the mechanism of Effexor inhibiting the serotonine and noradrenaline (or is that "norepinephrine" in english?) re-uptake.
I roughly know what effects noradrenaline has on the sympathetic-system (blood pressure increase, metabolism increase and so on...)and why that is so.I am asking for a particular reason. One of my friends is taking Effexor XR (150mg/day) and has massive sleep disorder (*broken* sleep plus waking up at 5:00 am and couldn`t get back to sleep again)
Now I wonder, whether Effexor could be the cause of this problems (or at least increasing them, as he had this problems before, but they got worse under Effexor)
I was trying to figure out the *why* of some of Effexor`s possible side-effects and interactions with other drugs on the basis of my little knowlegde, but, I could use a little help with that.Could you please explain me:
* what exactly does Serotonine do (physical and psychological effects)
* what effects does noradrenaline has on one`s psyche?And, what do you think about Kava-Kava to help his sleep disorder? I`ve heard Kava-Kava is discussed to have an effect on Serotonine re-uptake and being metabolized by CYP2D6 ?
Now, if that is true (I am not sure) that would mean Kava-Kava could cause a toxic Serotonine level - which would be as bad as combinating Effexor with MAO-inhibitors?
Thank you very muchMicha
PS: You might wonder, why I am not asking my boss. I am on holidays at the moment and the only way to do so would be to phone him, but I never know when would be a good time, as he`s usually very busy.
poster:mgrueni
thread:78136
URL: http://www.dr-bob.org/babble/20010907/msgs/78136.html