Posted by jay on September 17, 2001, at 6:55:50
I am curious about any substantial differences between the effects of dopamine and and norepinephrine. I'd like to know the *pronounced* differences, as I have partial response to meds that lower/control norepinephrine levels, including many blood pressure meds. I don't know exactly how it helps, but microdoses of Clonidine is amazing for controling sweating brought on by more activating a.d.'s, anxiousness, and others have helped with sleep, to that *out of control* anxious feeling mixed anxiety/depression brings. It is not consistent, though.I am wondering about the connection between norepinephrine and cortisol secretion. Do some blood pressure meds have effects on both?
One of the last comments that I ask about this, is that in the recent *excellent* book on Depression,
'The Noonday Demon', the author states Prozac, when it was first being developed in it's infancy, was targeted as a blood pressure med by Lilly.I honestly see a lot of hope for a toning down, or regulation, of our CNS through leveling out the highly stimulating chemicals like norepinephrine, cortisol, and maybe even hormones like testosterone and estrogen.
I also wanted to add, that I don't see why they don't go for regulation of the secretion of those chemicals, rather than just receptor amounts and sensitivity. (Like they increase norepinephrine in the synapse with many a.d's to even out receptor levels. Despite the success of a.d's, it still is far from proving *major* relief for many anxious depressives.)IMHO...just curious..
Jay
poster:jay
thread:78909
URL: http://www.dr-bob.org/babble/20010917/msgs/78909.html