Posted by pellmell on September 25, 2001, at 11:18:22
In reply to Re: booze+XR HAHAHAHAHA, posted by bigjake on September 18, 2001, at 11:07:12
> Why does XR cause sedaton if it helps increase the amount of Dopamine in ones system?
>You'd probably have to take about a gram a day for Effexor to affect dopamine reuptake. :) But...
> This to me is perplexing. SL, you stated that if I upped my dose, I would feel less sedated, but you also said that this drug made you too sedated to really function.
>
> I need a little help here on that. I probably missunderstood.
>...it starts to affect norepinephrine as well as 5HT reuptake in most people at doses above 200mg. More free norepinephrine in the brain tends to (among other things) give you more energy. It also changes the quality of the side-effects you might feel and might also do something to counter some serotonergic side-effects. You see the same sort of thing with Remeron: at low doses its antihistamine effects predominate, causing major drowsiness, while at higher doses its noradrenergic effects can overwhelm the histaminergic ones, giving you your energy back. (Unfortunately, that never happened for me...)
Anyway, I got a bunch of this info from this little article:
http://www.preskorn.com/columns/9911.html
I'd recommend browsing the rest of the Columns section of the site. They're pretty nifty.Hope I helped clear up some mystery. :)
-pm
poster:pellmell
thread:78744
URL: http://www.dr-bob.org/babble/20010917/msgs/79543.html