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Re: Sibutramine (Meridia) for depression. » SLS

Posted by Cam W. on October 7, 2001, at 12:34:26

In reply to Sibutramine (Meridia) for depression., posted by SLS on October 7, 2001, at 10:17:27

Scott - Okay, what is it with that stuff? It's "proposed" mechanism of action is serotonin and norepinephrine reuptake inhibitor, with a metabolite blocking dopamine reuptake 3 times less potently than the parent compound blocks the other two reuptake sites.

So, this makes it Effexor™ (venlafaxine)! Where the heck does the weight loss come from? I haven't checked out the relative binding potentials between Meridia™ (sibutramine) and Effexor, but this really baffles me. People still gain weight on Effexor (although not as much as with the SSRIs, esp. Paxil™ - paroxetine). What are they not telling us?

Things that make you go hmmmm! - Cam


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poster:Cam W. thread:80530
URL: http://www.dr-bob.org/babble/20011007/msgs/80549.html