Posted by kregpark@yahoo.com on October 17, 2001, at 2:08:46
In reply to Re: PROVIGIL POOP OUT, posted by houstongirl on October 16, 2001, at 9:14:09
Woops, just noticed something again forgot to mention.
I'm not sure what the Celexa and Depakote (sp?) are for ... (pause) ...
... I just looked on Internet, depakote = valproic acid???100 Celexa (pretty high dose) + Depakote just from the little I know about those sounds like a good chance to blunt much of Provigil's effect.
Again, not sure what the 2 meds are for but since I just read that depakote is anti-manic then it sounds like it may be sedating, and probably moreso combined with a pretty relaxing ssri like Celexa.
I'm just kind of curious if switching 1 or both of the original medicines might not be worth trying also, as an alternative option to finding a 3rd med to counteract sedation from the first 2.
> I am also interested in learning more about the anticonvulsant interaction with Provigil. Also about the Celexa. Where can I get more info, like to show pdoc? (kregpark, anything?) I'm currently on 1500mg Depakote, 100mg Celexa and 200mg Provigil and I'm STILL sleeping 10-12 hours a night. Waking up in the morning is next to impossible, even with a light box. All I do is dream that I can't open my eyes and I'm getting fired from my job...
>
> Thanks,
> Cristy
>
> > Hello,
> > Thanks for your response. Interestingly, I did start taking Lamictal at the same time I started the Provigil ... that would support your information that Provigil can be negatively affected by an anticonvulsant. Makes sense to me!
> >
> > Thanks again,
> > cindy
> >
> >
> > > Hi -
> > >
> > > I know that Provigil doesn't work for everybody.
> > > I was curious though; about the people who didn't have any success with it in the long run...if there may be drug interaction causing part of the problem.
> > >
> > > It is already known for example that Provigil and Celexa have a metabolic interaction which tends to make Provigil largely ineffective for Celexa induced sedation.
> > > On the other hand, Provigil has been shown effective for Zoloft, Prozac, and Paxil induced sedation.
> > >
> > > Others that may interact include anticonvulsants.
poster:kregpark@yahoo.com
thread:81227
URL: http://www.dr-bob.org/babble/20011015/msgs/81459.html