Posted by Cam W. on October 22, 2001, at 23:21:40
In reply to Re: Proposed Mechanisms of Action of Lamotrigine » Cam W., posted by Cindylou on October 21, 2001, at 14:25:26
Cindy - The dreaded rash (Steven-Johnson syndrome) is very rare in adults and affects mainly young children. I believe that the incidence of this is 1 in 1000 in adults (1 in 100 if including children), but the incidence of an ordinary, sunburn-like rash is about 1 in 10. The minor and major rashes are usually seen when the dose of Lamictal is raised too fast. Most docs will stop Lamictal at the first sign of any rash (with good reason). Upon rechallenge, at a lower dose, and slower titration, most people do not develop a rash when tried on Lamictal the second time around. I haven't noticed if anyone is more predisposed to the rash than other people, but I may be missing a link. - Cam
poster:Cam W.
thread:81710
URL: http://www.dr-bob.org/babble/20011015/msgs/82025.html