Posted by Elizabeth on October 28, 2001, at 10:36:21
In reply to Re: CA rocket fuel; modafinil pharmacology » Elizabeth, posted by JohnX2 on October 28, 2001, at 2:09:17
> How does one use Kd information?
Do you know any biochemistry? Kd (the d is supposed to be a subscript, BTW) is the dissociation constant (in this case, for modafinil at the dopamine transporter).
> For example Bupropion Kd info
> says that the med should do squat, but the
> researchers have determined that the metabolite
> hydroxybupropion does most of the work.Yes, hydroxybupropion does appear to be responsible for much of the therapeutic efficacy of Wellbutrin, but AFAIK, the mechanism of action of the metabolite is not understood either. Of course the pharmacology of the hydroxy metabolite will need to be determined if we are to find out what makes Wellbutrin an effective antidepressant. We also need to know the degree to which bupropion is metabolized into hydroxybupropion (this has probably been determined by now), and various other things -- this stuff is pretty complicated.
I don't have answers for your other questions, I'm afraid. Perhaps someone else could help us out here. (Also, I haven't started any CRF-like cocktail -- I'm still taking desipramine + buprenorphine + Trileptal. I promise to come up with a silly name for whatever I do end up taking, though. :-) )
-elizabeth
poster:Elizabeth
thread:81334
URL: http://www.dr-bob.org/babble/20011025/msgs/82484.html