Posted by PaulB on November 4, 2001, at 16:49:26
Why is Zoloft No1:
I was wanting to post this message because not only is Sertraline(Zoloft) the most commonly used antidepressant- http:www.rxlist.com -literature indicates that it is a very effective "antidepressant", specific parameters because Sertaline, I have read, can help very much with all conditions that are now commonly associated with a deficit of serotonin in the brain and has also been licensed for Post Trauamatic Stess Disorder. I have my beliefs as to the reasons why this may be but would like to know other people's opinions and also if people who have taken Sertraline can compare it with other SSRIs and have had better results with Sertraline. You see I only have noticed subtle differences in the effects of Paroxetine, Fluvoxamine and Sertraline.
I think there is some speculation that people who have been intitally prescribed Fluoxetine or Paroxetine may respond better to Sertraline because there is much less likelihood of liver or CNS tolerance due to increased enzyme activity that metabolises the SSRIs; the Cytochrome P450 collection of enzymes because Sertraline is taken at higher dosages[50mg-200mg].
I have a friend who was switched from Fluoxetine to Sertraline and found the latter ot be more effective.
Furthermore Sertraline has a reputation for what is described in a medication book I have as being 'middle of the road side-effects' and therefore is usually well-tolerated, yet it is only somwhat less potent than the most potent SSRI Paroxetine I believe in the line-up of SSRI's that are currently available. Intersting?
As to its recent licence to PTSD, is that worth considering as to why Zoloft is no1.
poster:PaulB
thread:83199
URL: http://www.dr-bob.org/babble/20011104/msgs/83199.html