Posted by Mitch on November 18, 2001, at 17:35:00
In reply to Re: new bupropion mode of action abstract- CAM,SLS,JG » Mitch, posted by JohnX2 on November 18, 2001, at 13:33:53
John,
I also have noticed a significant reduction in the need to "keep moving" (my restlessness/akathisia). I also feel less "pressured" to get everything done all at once. I feel actually somewhat emotionally "neutral", and relaxed. I don't have fifty things all going at once. The dystonia (tight throat muscles) from the tiny bit of Zoloft I take seems to be less and I am not grinding my teeth as much. I even was focused enough to SIT STILL for two hours and set up my own mood chart on a spreadsheet.
That is too bad you can't seem to get the WB to "work" for you. Maybe the nortriptyline you have been thinking about could kick-start it. I would take it at bedtime to start off, though. It is somewhat sedative (although I took it in the daytime, too in divided doses).Mitch
>
> Hey this is great news.
>
> I also get a *substantial*
> anxiolytic response from Wellbutrin.
> Supposedly it is effective
> for peripheral neuropathy from a report
> I recently read too.
>
> I really wish I could find
> a way to make wellbutrin work. The only
> other med that really cured my dysthymia was
> Adderall and it had its problems. WB is a
> good med if one can get it to work.
>
> I believe the anxiolytic action comes
> from its action in the locus coerulus area
> of the brain (the noradrenaline flight/fight)
> area. It increase norepinephrine, but slows
> down the firing which is usually anxiolytic.
> A lot of people get edjy on Wellbutrin, so that
> must be from some other interaction in the head,
> because slowing the LC almost always
> translates to less anxiety. Amphetamine
> slows the LC too and some people actually feel
> more calm on amphetamine than off amphetamine.
>
> regards,
> john
>
>
> > >
> > > This is quite technical, but for those who are
> > > interested:
> > >
> > > There was a new article in psychopharmocology
> > > on Wellbutrin's mode of action.
> > >
> > > Basically came to some of the same conclusions as
> > > another article I read, but also came up with 1 more
> > > piece of data which I always thought would be true:
> > > Bupropion increases serotonin conductance!
> > >
> >
> > John, et al,
> >
> > I can't explain why I feel so much better, since I have added on a low dose of bupropion. I seem to have improved sleep architecture like I had on Adderall without feeling panicky. I don't seem to have the *avoidance* I used to have. I really seem to be getting a paradoxical *anxiolytic* response to this med. I also have needed less Klonopin-I only took 1/4 of a .5mg tab all day today! I should be getting very sluggish and melancholic now (SAD symptoms-late fall/early winter), but it isn't happening. The best way to sum this up is like taking a pstim with little anxiety. I notice some improvement with attention-but nowhere as marked as with a pstim. But, there is no *degradation* of cognitive function that I normally experience at this time of year.
> > Go figure,
> >
> > Mitch
poster:Mitch
thread:84499
URL: http://www.dr-bob.org/babble/20011113/msgs/84593.html