Posted by spike4848 on January 22, 2002, at 23:08:14
In reply to Re: Anti-depressant Least Likely to cause cycling?(BP, posted by OldSchool on January 22, 2002, at 20:44:14
> Well, Im not bipolar but all the literature Ive ever read has said that Wellbutrin is the preferred antidepressant in bipolar disorder. One of the things about Wellbutrin is that while it is a mild dopamine reuptake inhibitor, it simultaneously restricts the release of dopamine. And thats good for holding back mania or psychosis. So thats one of the reasons why Wellbutrin is good for bipolar.> > Old School
Hey There,
Yes .... I heard the net effect of Wellbutrin on dopamine is zilch. Like you mentioned, it is a *VERY* mild ... if not negible dopamine re uptake inhibitor ... there maybe some inhibition of dopamine release by wellbutrin or one its metabolites as well. And maybe this is why lower incidence of cyclicing.
I alway wondered if this is why SSRIs may have a reduced incidence of cyclicing. The elevation of serotonin level inhibit dopamine release .... thus less induction of mania .... thus apathy in many individuals at high doses .... thus sexual dysfunction.
Thanks Old School.
Spike
poster:spike4848
thread:91108
URL: http://www.dr-bob.org/babble/20020116/msgs/91159.html