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Re: Prozac one went south!

Posted by djmmm on February 2, 2002, at 23:52:59

In reply to Re: Prozac one went south!, posted by OldSchool on February 2, 2002, at 18:12:13

> > > No. r-citalopram is supposed to responsible for the side-effects, at least for more side effects than s-citalopram. Thats why they leave the r-isomere away. Lilly is planning this with Prozac (fluoxetine) too.
> >
> >
> > The Prozac one didn't work out for Lilly because at higher doses R-Fluoxetine caused cardiac side effects. That has been ditched... The next big hope out of Lilly is Duloxetine. Another dual acting pump inhibitor.
>
> What a waste of time. We already have Effexor...same exact thing as Duloxetine.
>
> Old School
> >
> > Scott

oldschool,

Here's something, it's the (R) isomer of sibutramine (meridia)..it will be marketed for depression and ADHD...this may be interesting because it seems to be more selective to norepinephrine and dopamine than serotonin.

http://www.sepracor.com/pharm/

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10844103&dopt=Abstract


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poster:djmmm thread:91928
URL: http://www.dr-bob.org/babble/20020131/msgs/92674.html