Posted by JohnX2 on February 5, 2002, at 23:56:51
In reply to Buspar for SSRI induced bruxism., posted by mikel on February 5, 2002, at 8:20:36
Mike,There was a published paper about Buspar being
used as an anti-dote for SSRI induced bruxism.It listed 4 cases where Zoloft was the culprit
and patients were complaining of tension headaches
and teeth grinding. Anyways the results were pretty
good, but took about 2-3 weeks.The theory behind the SSRI induced bruxism had to do
with how the medicine interacts with a certain type of serotonin
receptor. Specifically too much serotonin hiting
the sertotinin "5ht-2" type receptor would blockade dopamine
release. The dopamine that was blocked was responsable
for inhibiting the contraction of muscles in the
face/head. Buspar would fix this by reducing
serotonin firing. Other meds could reduce this
by "blocking" the "5ht-2" receptors. And then
there are meds besides Buspar that also inhibit
serotonin firing ("Gaba" medicines).Anyways, there are a number of anti-dotes
that I'll list for you that you can discuss with
your pdoc.I think a better strategy is to augment the
SSRI with a medicine that blocks the serotonin
5ht-2 receptor. For this the best candidate to add on
is probably Serzone. You can add Serzone as an
adjunct to the SSRIs to combat the bruxism.
Remeron might also help. Blocking the 5ht-2
receptor will work more quickly than using
Buspar's method. Another aproach may be to
add on a low dose of Zyprexa or an equivalent
medicine.Finally, there are medicines that work on
the Gaba system. Some are potentially habit
forming, while others are not. I know for
a fact that people have reported luck with
Baclofen. I know for a fact that Klonopin works
too.So here is a list of candidates:
5ht-1a agonist add-on to an SSRI
- Buspar I give it a 50/50 shot. Takes 2-4 weeks.5ht-2 antagonist (blockers) add-ons to an SSRI
- Serzone best candidate. Take about 1 week
- Possibly Remeron, Zyprexa and friends. Take about 1 weekGaba medicines
- Baclofen , Klonopin and friends. Same day.Regards,
John> Anyone had any luck with treating SSRI induced bruxism with Buspar? SSRI's work the best for me, but Prozac, Celexa and Effexor all cause jaw pain due to bruxism exacerbating my TMJ. As soon as I go off the SSRI the jaw pain stops, but the depression returns. Tried Serzone, did not work as well on the depression. I am currently on low dose prozac(10mg), but still get the bruxism, so I am now starting on Buspar. What dose have people tried that worked and how long did it take?
> Any other meds people have tried?
poster:JohnX2
thread:92947
URL: http://www.dr-bob.org/babble/20020131/msgs/93037.html