Posted by JohnX2 on February 9, 2002, at 21:01:35
In reply to Re: Lamictal as anti-depressant- how? what doses?, posted by djmmm on February 9, 2002, at 4:07:17
Hi,
Ok, This would explain my response to Neurontin.
I always got weird dreams on that one. Gotta be
serotonin!Lamictal dosage bumping giving me Zoloft like
effects.Anyways, 3Beer, maybe you could take a low dose
of Zyprexa to help offset any mania/irritation that
Lamictal would induce?Regards,
John
> > I am starting with 25 mg of lamictal/day as a mood-stablizer/antidepressant & my dose is to be increased by 25 mg each week. I am quite depressed & was wondering at what dose range does Lamictal work as an anti-depressant. Is Lamictal as strong of an antidepressant as the SSRIs (which I can't tolerate-mania/insomnia). I take the lamictal once at night because it seems to cause nausea for me- Why do some people take it twice a day if the half life is 32.8 hours?
> >
> > Why does Lamictal have anti-depressant properties? It only has a "weak inhibitory effect on the serotonin 5HT3 receptor & weak effects at sigma opoid receptors." "Lamictal did not inhibit the uptake of serotonin, norepinephrine, dopamine, or aspartic acid."
>
> Lamictal *does* inhibit the reuptake of serotonin *and* norepinephrine *and* dopamine
> (Eur J Pharmacol. 1998 Sep 25;358(1):19-24.)
>
> most mood stabilizers have some serotonin activity:
>
> Tegretol: stimulates strotonin
>
> Neurontin: increases serotonin concentrations in human whole blood
>
> lithium: may increase density and sensitivity of 5ht2 receptors
>
> depakote: may increase serotonin activity via 5ht1a autoreceptors
>
> etc, etc
poster:JohnX2
thread:93340
URL: http://www.dr-bob.org/babble/20020208/msgs/93519.html