Posted by IsoM on February 15, 2002, at 23:31:00
In reply to Re: Adrafinil will never see our shores: Never:(, posted by Michael D on February 15, 2002, at 22:40:57
Michael, all drugs when they're metabolised & not excreted unchanged, are metabolised by the liver. Some drugs can be harder on the liver than others. Acetaminophen (Tylenol) is one the worse drug for the liver (its chief metabolite is very poisonous). It isn't that adrafinil or modafinil is toxic to the liver, but the liver is the major processing plant of the body where all chemicals other than nutrients undergo changes before being excreted from the body. (The explanation is a little simplistic but just trying to give you an idea).
Different drugs use different enzymatic pathways in the liver for metabolism. I'm NOT advocating anything on this site but this link will give you a quick rundown on *how* the liver works, if you're interested in educating yourself about these matters:
http://www.garynull.com/Documents/Continuum/LiverOfTheMatter.htmAnyway, in a healthy individual, the liver can handle adrafinil & modafinil, but due to differences in our genetic make-up, in our health, diet, other meds, & enviroment, people's ability to metabolise different medications vary. Hence, the need for regular liver enzyme level checks.
poster:IsoM
thread:94296
URL: http://www.dr-bob.org/babble/20020215/msgs/94354.html