Posted by JohnX2 on February 19, 2002, at 15:49:17
In reply to tools to offset Serzone cognitive issues?, posted by JohnX2 on February 18, 2002, at 15:30:52
hmm....I found a link between medicines that block
serotonin 5ht-2 receptors and histamine turnover.
(Of course I can always find a link for anything).
I don't know if this somehow explains why Serzone
is ridding me of these aweful headaches as well
as the anti-histmine chlorpheniramine maleate.
This link discusses olanzapine (Zyprexa), which
I am taking but have not found as effective as
Serzone was for these facial neuralgia symtoms.I found some interesting articles discussing how
anti-histamines can increase NMDA and hence dopamine
production in the limbic area of the brain. The
thing I find from taking this chlortrimeton is that
in massive doses it totally stabilizes my mood,
reenables stimulants to work, starts a nasal drip
(unclogs my sinuses), and totally cures in a
very interesting way this long standing feeling
of inner restlessness. But I have to take a whopper
of a dose (note the anti-histamine HAS NO decongestant).
So I think I should see an allergist.Pharmacol Exp Ther 1999 Feb;288(2):590-6 (ISSN: 0022-3565)
Morisset S; Sahm UG; Traiffort E; Tardivel-Lacombe J; Arrang JM; Schwartz JC
Unite de Neurobiologie et Pharmacologie Moleculaire (U.109) de Institut National de la Sante et de la
Recherche Medicale, Paris, France.
Clozapine and olanzapine behave as weak H3-receptor antagonists in vitro with Ki values around 1 and
50 microM, respectively. Despite these modest apparent affinities, both compounds given orally to mice,
nearly doubled steady-state tele-methylhistamine levels in brain, with ED50 values as low as 1 and 3
mg/kg, respectively, an effect comparable to those of potent H3-receptor antagonists. This effect
corresponded to an enhancement of histamine turnover rate from 45 to 73 ng/g/h as measured in the
case of olanzapine using the pargyline test. Other antipsychotics displaying, such as clozapine and
olanzapine, high 5-hydroxytryptamine (5-HT)2A receptor antagonist potency, i.e., risperidone,
thioridazine, seroquel, and iloperidone, also enhanced markedly tele-methylhistamine levels. This effect
was 1) additive with that of a pure H3-receptor antagonist, ciproxifan, 2) mimicked by a 5-HT2A receptor
antagonist, ketanserin, 3) reversed by a 5-HT2A receptor agonist, DOI, 4) not shared by antipsychotics
with low affinity for the 5-HT2A receptor, i.e., haloperidol, sulpiride, raclopride, or remoxipride that, on the
contrary, tended to reduce tele-methylhistamine levels. We conclude that in contrast to "typical"
antipsychotics, "atypical" antipsychotics stimulate histamine neuron activity via blockade of the 5-HT2A
receptor in vivo. This effect does not appear to account for their reduced extrapyramidal side-effects but
may underlie their pro-cognitive properties.>
> I may be starting Serzone again as it is
> the only medicine besides Topamax that alleviates
> really bad tension headaches and I am having
> an impossible time tapering off this last 1 mg
> of Klonopin.
>
> Funny, I found Topomax alleviated
> my myofacial pain that Klonopin seemed to be
> doing and swiftly weened Klonopin from 6 mg to
> 2 mg, but from 1 mg downward the headaches have
> been unbearable.
>
> So I'm thinking of maybe restarting Serzone.
> It totally eliminated these headaches before, and
> I may be able to take it if only for a short while
> to chip off this last mg of Klonopin. The major
> issue is that Serzone caused in the past very
> bad cognitive dysfunction and it was a bit scary
> to operate my car.
>
> So my question is if people have tried augmenting
> serzone with other meds to help with cognitive
> side effects? Any other ADs or stims?
>
> Thanks for any feedback.
>
> -John
poster:JohnX2
thread:94516
URL: http://www.dr-bob.org/babble/20020215/msgs/94670.html