Posted by petters on February 21, 2002, at 21:02:02
In reply to zyprexa a cognitive enhancer augment? interesting, posted by JohnX2 on February 21, 2002, at 17:29:08
>
>
> Before I started Zyprexa I was worried that it
> would make me really dizzy because it blocks a
> alpha-1 noradrenaline receptor in a manner similar
> to Serzone. But alas I found that Zyprexa does
> not cause cognitive disfunction. Since then I
> also have taken strong doses of Topamax and
> also Neurontin without cognitive decline. Is
> the Zyprexa helping?
>
> I was postulating differences between Serzone
> and Zyprexa when investigating some thoughts
> about allergies and depression. When I start
> Serzone I get a really bad flush in my face and
> I feel really dizzy. This is consistent with getting
> a histamine shot. There is a histamine feedback
> receptor that inhibits the release of histamine,
> serotonin, noradrenaline, and acetylcholine. This
> effect will cause a cognitive decline. I believe
> on Serzone this effect can make one feel a bit
> "drunk".
>
> Anyways both Serzone and Zyprexa still cause
> weight gain by blocking the alpha-1 noradrenaline
> receptor (makes you hungry). But Zyprexa has this
> nice little widget that slightly antagonizes the
> histamine "h3" feedback receptor and thus is a
> pro-histaminergic medicine. I believe it will increase the
> release of the monoamines noradrenaline, acetylcholine,
> serotonin. Possibly this offsets any cognitive
> declines from blocking the noradrenaline receptor.
>
> So now that I take Zyprexa, my pdoc puts me back
> on Serzone and I predict that I wont get all drunk
> and have hot flashes and I am correct.
>
> Ergo, I believe a pinch of Zyprexa (5 mg) can be
> used as an adjunct to Serzone and maybe even
> mood stabilizers to help with cognitive declines.
>
> Thoughts.
>
> -John
Hi John.I´m using Serzone toghter with Effexor. I have use Effexor + Remeron for two years. This combo was very good for my cognition. Because of excessive weightgain from Remeron I switched to Serzone.
Serzone + Effexor is good for the depression, but I have notice a clear cognitve decline after starting Serzone.
I have been on Serzone for five weeks. Can this side effect alliviate after some month?
I have also constipation from Serzone.Any ideas?
Sincerely...//Petters
poster:petters
thread:95013
URL: http://www.dr-bob.org/babble/20020215/msgs/95051.html