Posted by JohnX2 on February 22, 2002, at 12:31:45
In reply to Serzone vs. Imitrex for headaches question?, posted by JohnX2 on February 22, 2002, at 11:54:27
Note, I seem to be wrong about mCpp. It is an agonist
presumably at selective 5ht receptors, which
Im not sure yet.-john
>
> I once tried Imitrex for my headaches at my
> GPs office and they stuck a big ugly needle
> in my arm and it turned my skin all red.
> It seemed to help my headache a little for a while,
> but I didn't have the symptoms of migraine that
> they asked about.
>
> Serzone is definately helping alleviate my
> headpain (as well as Klonopin and Topamax). Serzone
> was the only AD to do so. Others made it worse
> including Zoloft. When I take Serzone it also causes
> my skin to flush in a manner similar to the Imitrex
> shot.
>
> I'm thinking the Serzone flush is caused because
> Serzone has a metabolite mCpp that is a dirty
> serotonin agonist whereas Imitrex has a cleaner
> metabolite that is selective for the 5ht-1b and
> 5ht-1d receptors. Anyways both meds are therefore
> agonists at those receptors. The only other SSRI to cause
> this flush for me was Paxil, but it didn't work
> as an AD.
>
> Anyone else experience this flushing in the
> skin and get relief from migraines or other
> types of headaches?
>
> -John
poster:JohnX2
thread:95100
URL: http://www.dr-bob.org/babble/20020222/msgs/95107.html