Posted by mike21 on February 26, 2002, at 20:08:01
In reply to Re: selegiline stuff » Jason911, posted by JohnX2 on February 23, 2002, at 15:19:07
>
> In regards to Wellbutrin, the medicine long term inhibits
> firing in an area of the brain called the "locus coeruleus".
> This is a central noradrenergic nucleus that is very sensitize
> to stress. Wellbutrin has metabolites that are potent norepinephirine
> reuptake inhibitors that long term desensitize the alpha-2 feedback
> receptors in this area of the brain which causes the firing rate to
> slow down. This causes a net increases in norephinephrine in the synapse
> with a slower firing rate. The slower firing rate gives reduced anxiety.
> But it takes time for the alpha-2 feedback receptor to be downregulated.
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.
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> You can really increase the power of Jumex by taking Remeron,
> but you are playing with fire and will be really anxious.
> The Remeron antagonizes the alpha-2 feedback receptor and I think will
> increase the tyrosine hydroxylase enzyme. This
It seems that remeron would actually block wellbutrin from performing its main action: desensitizing the alpha-2 feedback receptor. I was recently prescribed both, but am now questioning the point of using both at once. I guess it could be that the wellbutrin is somehow meant to augment remeron and some of its side-effects. What are your thoughts?Mike
poster:mike21
thread:95046
URL: http://www.dr-bob.org/babble/20020222/msgs/95633.html