Posted by JohnX2 on March 1, 2002, at 0:48:19
In reply to Re: old pbabble posts for dopaminergic meds. » JohnX2, posted by Jason911 on February 28, 2002, at 21:18:57
Jason,A lot of depression has to do with dysregulation of
the HPA (hypothalamus-pituitary-adrenal) axis. Generally
in chronically depressed patients there is excessive
stimulation of the HPA axis. This is thought to be caused
by downregulated glucocorticoid receptors. The adrenal glands are responsible for
indirectly regulating the production of (nor)adrenaline.
With a dysfunctional HPA axis, this system will
be dysfunctional and you can forget about getting a
robust noradrenergic/dopamine response. SSRI medications help to correct malfunctions
in the HPA axis, thus normalizing the noradrenaline and
dopaminergic systems also. Norepinpherine reuptake
inhibitors can do this too in different ways. Same for
healthy MAOI doses. So its really not all that
simple to discount one system vs. another. But it takes
time and a healthy dose for an anti-depressant to cause
this cascade of biological changes to take place.
For example, I find it odd that you do not get a response to amphetamines.
This could point to a dysruption in your HPA axis, who knows.Btw, what are your symptoms? Major Depression,
Dysthymia, bipolar, etc?A good website to understand these interactions is:
http://www.acnp.org/g4/
> Thank you very much for your posts. Indeed I HAVE read alot of posts by Andrew and wondered myself why he hasn't posted lately. I guess he found a group of meds that have worked and hasn't needed to come back to post very much as he could be now "cured". I don't know, but I too believe (like I said before) that 60% or more of depressed people are so because of dopamine related problems and not serotonin like people tend to believe now. The SSRI's just mask the depressed individual who's problem is dopamine. Like a safety net. Alot of recreational drugs have a dramatic effect on serotonin and the SSRI's sort of give those people that buzz and slight mood lift but don't cure the people depression completely in my mind. It just makes their lives managable for once in their life. But don't get me wrong, there are people who do have serotonin related depression and the SSRI's have worked wonders in those people (although some are affected by those dreaded side-effects, but I guess feeling better outweights a side-effect or 2 or 3 or 4) Memantine isn't available anymore (I would have used it along time ago if this weren't the case) like I said in my precvious posts as well as amineptine, which was another great dep-med for dopamine-related depression. But I guess those meds worked so well that they took them off the market. Damned those FDA pricks. They are denying us our potential "cures", ya know? I will look into amisulpride but I don't think that is even available anymore. Thanks for your comments. And how do I search for past posters like Andrew B. I know how to search for names like selegiline+klonopin, but how to I search for specific posters??? I need a cure for my dopamine-related depression!!!! My Jumex comes in about 2 and a half weeks and I'll let everyone know how that goes with the Klonopin. I'm off the Wellbutrin because it didin't do anything mood-wise and just increased my anxiety. Since being off the bupropion, my optimal dosage of Klonopin is 3mg/day. I feel great and relaxed and anxiety free now!!! That's one step. The next is relieveing the slight mental fog that is created (which I believe the Jumex will help) and I still have trouble effeciently concentrating. JohnX, you're a cool guy. Keep me up to date... -Jason911
>
>
>
> >
> > Jason,
> >
> > A wizard of dopaminergic medicines on psychobabble
> > was AndrewB. No one will deny this. He is an extremely learned and
> > intelligent individual. He hasn't been posting much on this news
> > group lately.
> >
> > He is really smart and believed strongly in going straight
> > after dopamine as a depression treatment. He researched thoroughly
> > most of the dopaminergic medicines and tested a lot of them himself.
> >
> > Anyways, if you want to look into dopamine, I would dig through
> > old pbabble posts for AndrewB posts.
> >
> > He was really hot for a medicine called amisulpride which blocked
> > the dopamine autoreceptor.
> >
> > The latest cocktail he was on included (I don't remember the doses):
> >
> > amisulpride
> > adderall
> > memantine
> > klonopin
> > selegiline
> >
> > The selegiline was low dose from what I remembered primarily for
> > neuroprotective properties. He also experienced poop out issues
> > with Adderral, and the memantine medication alleviated the tolerance
> > issue to Adderall. He also believed that memantine could prevent
> > risk of tardive dyskinesia from amisulpride.
> >
> > -John
> >
> >
> >
> > > I need to know if anyone has had success with low dose dprenyl as a cogntive enhancer in combination with meds that can make you drowsy or if you have used it and noticed different effects, such as elevated mood, increased libido, etc..? Thanks -Jason911
poster:JohnX2
thread:95591
URL: http://www.dr-bob.org/babble/20020222/msgs/95911.html