Posted by Bob on March 2, 2002, at 14:02:48
In reply to When is duloxetine to be approved?, posted by SLS on March 1, 2002, at 9:48:21
What is expected from Duloxetine that we don't already get from Effexor, except possibly a slightly different response profile? Effexor has many problems for many people, and I don't see how Duloxetine will be any better. I don't doubt that the med will produce robust sexual dysfunction, and weight gain in the long run. It may have a severe withdrawal syndrome like that of Effexor too. Nobody will be able to tell you from a short FDA study, though. Why won't this med me subject to poop-out, like so many of the SSRIs, and Effexor? It seems to me that the medical/pharmaceutical community has not addressed the fact that eventually in many cases, the brain adapts to the drug, and effectiveness is lost. I'm not sure the drug companies care, though, as long as a majority of people respond for appreciable amounts of time. The non-responders can be considered a "difficult minority".
I hate to be negative, but I can't really help it anymore.
poster:Bob
thread:95939
URL: http://www.dr-bob.org/babble/20020301/msgs/96083.html