Posted by TSA West on March 2, 2002, at 16:49:49
In reply to ANY SUCCESS-MOCLOBEMIDE AND ATYPICAL DEPRESSION?, posted by DINGBAT on March 1, 2002, at 9:20:29
"We report on the efficacy and apparent tolerability of moclobemide at doses of up to 1,650 mg/day in 13 patients (4 men, 9 women) with major depressive disorder who had been resistant to at least two prior conventional antidepressant treatment trials at standard or higher doses and/or electroconvulsive therapy (ECT). A majority of patients were resistant to a minimum of four trials of antidepressant treatment and/or ECT. Four patients had been unable to tolerate antidepressant therapies at adequate doses and durations. Treatment was initiated at the usual doses of moclobemide, ranging from 300 to 450 mg daily, and progress was monitored. If there was no improvement in mood, doses of moclobemide were progressively increased in 150-mg increments every 2 to 3 weeks, as tolerated, up to a maximum dose of 1,650 mg during a period of 3 to 12 months. It was decided to gradually increase the moclobemide dose with the goal of achieving improvement; the treatment would be discontinued if there were significant adverse events. Lithium augmentation (600-900 mg/ day) was used in some cases to enhance the response at higher doses of moclobemide. Trazodone was administered at a subtherapeutic dose of 25 to 150 mg/day when insomnia was reported...The Clinical Global Impression Scale-Improvement subscale (CGI-I)11 from the initiation of moclobemide treatment to the highest tolerated dose of moclobemide, as well as the Hamilton Rating Scale for Depression (HAM-D, 17-item)12 in some cases, were used to assess mood over a period of 3 to 12 months, depending on each patient's course of therapy. According to scores on the CGI-I, it was found that 7 (54%) of 13 patients were "very much" improved or "much" improved while receiving high-dose moclobemide therapy in combination with trazodone and/or lithium augmentation in some cases. This improvement was maintained for periods of up to 2 years."
--Journal of Clinical Psychopharmacology, June 2000. "Tolerability and Efficacy of High-Dose Moclobemide Alone and in Combination With Lithium and Trazodone"
poster:TSA West
thread:95935
URL: http://www.dr-bob.org/babble/20020301/msgs/96095.html