Posted by SLS on March 11, 2002, at 13:04:02
Hi.
I wanted to repost this question because it wasn't on the board for very long before it was turned-over.
Has anyone used aripiprazole to treat depression?
How soon will it become available?
This drug shares properties with:
- DA D2 receptor antagonism: Zyprexa Geodon Risperdal
- DA D3 agonism: Mirapex
- 5-HT2 receptor antagonism: Zyprexa Geodon Risperdal Serzone Remeron
- 5-HT1a agonism: Geodon Buspar
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Excerpts from Medscape article:
http://www.medscape.com/viewarticle/422878
"Stephen M. Stahl, M.D., Ph.D., Professor of Psychiatry at the University of California at San Diego, places aripiprazole in the class of antipsychotics called dopamine system stabilizers (DSSs)."
"Pharmacologically, the DSSs mechanism is known as partial agonist action, meaning activation at low dopaminergic tone and inhibition at high dopaminergic tone. The result is stabilized dopamine output."
"The stabilization of the dopamine and serotonin systems is critical in managing the symptoms of schizophrenia. Stahl refers to his "Goldilocks" theory to explain the design of the DSSs. They are meant to preserve or enhance dopaminergic neurotransmission where it is low ("too cold") and reduce it where it is too high ("too hot"), according to Stahl."
"Aripiprazole acts more like a dimmer switch," says McQuade. "It's a modulator or stabilizer that goes to certain serotonin receptors."
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Aripiprazole receptor binding profile:http://sl.schofield3.home.att.net/medicine/aripiprazole_binding.pdf
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- Scott
poster:SLS
thread:97462
URL: http://www.dr-bob.org/babble/20020307/msgs/97462.html