Posted by johnX2 on March 13, 2002, at 14:58:01
In reply to naltrexene for SSRI poopout???????????, posted by JohnX2 on March 13, 2002, at 14:05:22
Ok, Part II of my research trek.
NMDA receptor link established (duh, surprise).
Will follow with partIII...Note: Naltrexone is an opiod antagonist
I'm curious if this can cause some sort of
indirect NMDA antagonism. I've looked at this up the wazoo in regards to stimulant tolerance (memantine and friends, hmmm would naltrexene prevent dexedrine tolerance? seen a serotonin link to amphetamines)Opioid-NMDA receptor interactions may clarify conditioned (associative) components of opioid analgesic tolerance.
Neurosci Biobehav Rev 2001 Jun;25(4):343-53 (ISSN: 0149-7634)
Bespalov AY; Zvartau EE; Beardsley PM
Department of Psychopharmacology, Valdman Institute of Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Str., St Petersburg 197089, Russia. abespalov@spmu.rssi.ru.
Recent evidence suggests that acute administration of opioid analgesic drugs (such as morphine or heroin) produces delayed hyperalgesia. This hyperalgesic response is likely to result from hyperactivation of NMDA receptors triggered by stimulation of opioid receptors and may mediate acute tolerance. In support of this hypothesis, blockade of NMDA receptors attenuates opioid-induced delayed hyperalgesia and prolongs the duration of antinociceptive activity of morphine. Furthermore, the NMDA receptor-induced hyperalgesia is likely an unconditioned response to opioid receptor stimulation that becomes spatiotemporally associated with environmental cues accompanying repeated opioid exposure. This hypothesis conforms to the traditional Pavlovian requirement for conditioned and unconditioned responses to be qualitatively similar. In support of the role of NMDA receptor hyperactivation in morphine tolerance, NMDA receptor antagonists have been shown to block development of analgesic tolerance induced by repeated exposures to morphine. The view of the conditioned nature of opioid tolerance may be significantly extended by assuming that upon repeated drug administration an early-onset effect of a drug may become a predictive stimulus for a later-onset effect and, consequentially, it may become empowered to elicit the later-onset effect itself. Such 'intra-drug' conditioning hypothesis is well in line with the current experimental evidence but further studies will be needed to verify it directly.>
> I saw this in the tips section.
>
> Does this really work? I am quite intrigued?
> What is the hypothesis if it does?
>
>
> -John
>
>
> (plagerize):
> Date: Fri, 16 May 1997 09:20:19 -0700 (PDT)
> From: ferrell@cmgm.stanford.edu (James Ferrell)
> Subject: Naltrexone for SSRI poop out
>
> Lee Dante wrote, in part:
>
> This phenomena of the SSRI "poop out" can usually be reversed by adding 25 mg of naltrexone (marketed in the US as Revia), usually on top of supper to avoid
> transient nausea. In anywhere from two weeks to five of once daily dosing the SSRI regains the full effect and often is perceived as working better than it did at
> first. I have done this in over forty cases where this has been most gratifying. At this dose of naltrexone the incidence of side effects is very low, and the
> improvement is sustained over a period of years. It has been the end of poop out in my practice.
poster:johnX2
thread:97807
URL: http://www.dr-bob.org/babble/20020313/msgs/97809.html