Posted by Janelle on March 17, 2002, at 14:23:10
In reply to Re: Weight Gain from TCAs and Benzos for Sleep » fachad, posted by JohnX2 on March 17, 2002, at 2:15:57
John,
Here I am again, back to pick your brain! Okay, you said that a lot of these medicines block the "alpha-1" noradrenaline receptor as well as the histamine receptor (I follow that!) and that this "alpha-1" receptor affects your metabolism, and that blockade of alpha-1 receptors or antihistamines can induce drowsiness.
You also said that you gained quite a bit of weight on Zyprexa and Serzone (both alpha-1 antagonists) so my question is: does the BLOCKADE of alpha-1 receptor and the metabolic changes this causes then result in weight gain?
I have been on Zyprexa for about a year - when I started on it my appetite became immense but I did NOT give into it (that was difficult but I managed). My depression had *helped* me in one way - I had lost my appetite and shed about 30 pounds which I really needed to lose. So when Zyprexa started giving me the munchies big time I just drank water or ignored them. After awhile the Zyprexa stopped increasing my appetite.
I'm surprised that you never gained weight on Remeron - just about everyone I read about who's on that one gains weighton it.
So, what's the story with weight gain - is it the blocking of the alpha-1 receptor that causes it? Thanks as always.
poster:Janelle
thread:98391
URL: http://www.dr-bob.org/babble/20020313/msgs/98458.html