Posted by Ritch on March 21, 2002, at 10:53:45
In reply to Re: SAM-e » Ritch, posted by Ron Hill on March 21, 2002, at 4:08:50
> > I have been feeling even better lately.
>
> Mitch, I'm really glad that the SAM-e add-on is working well for you so far. How much are you currently taking? Still 250 mg?Oh, just a 200mg enteric tablet in the morning. I used to take *all* my vitamins/flax/SAMe, etc at lunch. Too many pills at once! So, I do the SAMe and sublingual B-complex in the morning first thing and then make coffee (with a 100mg Neurontin). I notice that on an empty stomach I do feel just *slightly* queasy, but NOTHING like taking a larger dose of an SSRI (esp. Zoloft). Celexa gives me heartburn and reflux within about 2 hrs of taking it. I will be trying low-dose escitalopram when it is available to see if that is significantly reduced. BTW, I think the SAMe is helping ADHD symptoms. I can tell when those improve because they are directly correlated with my ability to pick out words in lyrical music.
>
> >I am only taking Celexa 2.5mg 3x weekly (my only antidepressant). But, I am taking 2.5mg of Dexedrine every day (afternoons). I really must say-that with the SAM-e addition I almost feel like I could stop the Celexa. I have found more hypomania symptoms with it than I have the dexedrine or the SAM-e, even at its microdose. The thing is whether panic will start returning if I ditch it. Will SAM-e have any sort of antipanic effect that AD's typically provide for folks with PD??
>
> I believe the answer is yes, however, since I do have PD as part of my formal dx, my experience may differ from yours. But for me, I have been pleasantly surprised by what I will call (for lack of a better term) a "soothing, calming, anti-irritability" effect. YMMV.
I probably will do OK, because I am already on .5mg (sometimes a little more) of Klonopin. I just worry about receptor "upregulation" occurring from not taking an AD and that leading to panic symptoms reemerging. But, of course that is all theory stuff.>
> A couple of days ago, when you were so kind as to send me a list of your current meds, your wrote:
>
> >Depakote 125-250mg hs (no tremor with Flax oil and the SAM-e!)
> Klonopin .5mg hs
> Neurontin 100mg tid
> Dexedrine 5mg/day
> Celexa 2.5mg every other day
>
> Your note after the Depakote dose intrigues me. What I read into your statement, and please correct me if I'm wrong, is that at one point in time Depakote caused tremors in you hands. But with the flax seed oil and SAM-e add-ons, the tremors are gone. Do I have it right? If so, my read would be that Depakote can, in some cases like yours, deplete dopamine levels. And, further, SAM-e and/or flax seed oil restore DA levels and/or DA transmission.
>
> -- Ron
Oh, I should have explained that in more detail. I actually attribute it to the three way add-on of the SAMe, flax, and dexedrine to elminating the tremor. I was up to 250mg of Depakote at bedtime for several nites in a row (from 125mg hs), and I expected my left hand tremor and left eyelid flutter to start happening again. It hasn't. I am a little impressed. I am beginning to wonder if my pdoc suspects some early onset Parkinson's and is allowing me to tinker with the pstims a little to see if some of my dystonia and med-induced tremor will just "go away". The last bout of dystonia was triggered from atypical AP's and it faded VERY slowly.Mitch
poster:Ritch
thread:98301
URL: http://www.dr-bob.org/babble/20020318/msgs/99203.html