Posted by JohnX2 on March 26, 2002, at 2:58:01
In reply to Re: NMDA theory of schizophrenia, etc. » JohnX2, posted by christophrejmc on March 25, 2002, at 23:34:30
> > It seems a lot of people aren't in harmony on this pcp based theory of schizophrenia.
>
> Fer sure. It is interesting that the NMDA-antagonists induce both positive and negative symtpoms (or do the other psychotomimetic drugs do this as well?)... Perhaps this will lead to a novel treatment for the oft ignored negative/cognitive symptoms of schizophrenia.
>
> There seems to be a dearth of information regarding neuroleptic-resistant schizophrenia. My psychiatrist (who spent a while practicing in one of our many long-gone (damn republicans!... sorry) psychiatric hospitals) told me that the hallucinations are often quite unresponsive to neuroleptic treatment.
>
> > BTW, how is the Selegiline trial going?
>
> Slowly. I'm at 30mg now and am getting some mild, but annoying cardiovascular side effects. It's effects on mood are strange... slight elevation but with no blunted affect (I'm a chronic apathetic partial responder).
>
> Are you still thinking about adding Li to your current regime? SLS's posts have me interested in trying low-dose Li. I didn't have any side effects for the one(!) day I was on it before.
>
Yes, I am probably going to do the Li trial this week. I am too unstable and out of mood stabilizer options. I could try to push my Lamictal dose, but this has caused problems in the past. The Li trial is quick as most people feel an effect rapidly, so I may as well give it a go + I feel I likely need a low dose.I would like to try Acamprosate or Memantine as atypical mood stabilizers and to help with a dystonia, but it may be a hard sell with my pdoc. I'm more into these natural compounds like Acamprosate (a taurine derivative) or neuroprotective meds (Memantine). I once tried taking a low dose dxm concurrent with Wellbutrin and I was able to get a sustained Wellbutrin response without tinnitus or headache or poopout, but I aborted the crazy experiment as the dxm half life was too short and required crazy dosing plus it could be toxic (although I wasn't hallucinating or anything). You need for a CYP2d6 inhibitor as in the Neurodex med to make this dxm a feasable medicine. It was amusing, but a silly thing to do. I also get poop out on amphetamines, so I thought the nmda antagonist medicines may be interesting for me to try (memantine being a safe one, acamprosate too).
Take care.
John
> Cheers,
> Chris
poster:JohnX2
thread:99188
URL: http://www.dr-bob.org/babble/20020322/msgs/100198.html