Posted by JohnX2 on March 26, 2002, at 18:09:13
In reply to modafinil (Provigil) and Serotonin, posted by JohnX2 on March 26, 2002, at 17:48:16
1: Neurosci Lett 1999 Jan 15;259(3):181-5 Related Articles, Books, LinkOut
Effects of the vigilance promoting drug modafinil on the synthesis of GABA and glutamate in slices of rat hypothalamus.Perez de la Mora M, Aguilar-Garcia A, Ramon-Frias T, Ramirez-Ramirez R, Mendez-Franco J, Rambert F, Fuxe K.
Department of Biophysics, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City.
The effects of the vigilance promoting drug modafil were studied ex vivo (100 mg/kg; i.p.) and in vitro (10-1000 microM modafinil) on the synthesis of [3H]gamma-aminobutyric acid ([3H]GABA) and [3H]glutamate from [3H]glutamine within the rat hypothalamus. No effects of modafinil were observed on the overall synthesis of these neurotransmitters nor, in vitro (1-33 microM modafinil) on other parameters related to the compartmentalization of their synthesis (glutamate decarboxylase and phosphate-activated glutaminase activities, and [3H]glutamine uptake). It is suggested on these grounds, that the modafinil-induced reductions and increases in regional GABA and glutamate extracellular levels respectively using in vivo microdialysis may be a consequence of an indirect effect of modafinil on these neurons.
PMID: 10025588 [PubMed - indexed for MEDLINE]
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