Posted by fachad on March 23, 2002, at 23:47:57
In reply to FACHAD: re Serotonin and TCA's » fachad, posted by Janelle on March 23, 2002, at 20:40:50
I don't know where you read that statement, but histamine and serotonin are massively distributed all thought the entire human body.
When you rub up against a bush that you are allergic to, the "weal" or hives is from histamine flare up.
SSRIs cause abdominal distress by affecting the serotonin in the GI tract.
Ondansetron, the most potent anti-nausea drug ever, works by blocking serotonin in the GI tract.
> Fachad,
>
> Just a coincidence but the first AD I was on was Elavil, and it got me to sleep like a baby the first week or so I was on it, then that sedating side effect wore off, as did the anticholinergic ones.
>
> Now, you wrote in another thread somewhere that serotonin occurs in the synapses of the intestines (or someplace within the digestive system), but look what I found in the link that Iso posted:
>
> "Serotonin (also known as 5-hydroxytryptamine or 5HT). Synthesized from tryptophan (Trp).
> Histamine
> Both of these neurotransmitters are confined to synapses in the brain"
>
> Based on this, there is NOT serotonin anywhere in the body but the synapses of the brain. But you said there's serotonin in the digestive system .... hmmmm ... I'm now confused again!!
>
> What do you think of this?
> -Janelle
poster:fachad
thread:99599
URL: http://www.dr-bob.org/babble/20020322/msgs/99765.html