Posted by JohnX2 on March 31, 2002, at 12:56:02
In reply to Re: dopamine and cognition cocktail for me » JohnX2, posted by Ron Hill on March 31, 2002, at 12:32:47
Hi Ron,
I'll take a good look over the post and get back shortly.
One thing I'll point out about my latest "dopamania" is that probably caffeine is playing a large role. I think the medicines are just "setting me up" biologically to allow stimulants to work easily. Wellbutrin was another AD that did this for me.
I got bad poop-out on stimulants and found was doing some research recently on AMPA receptors (which topamax modulates) and how they are involved in the sensitization of dopamine receptors. I think that may be where the Topamax is doing some work (it modulates AMPA glutamate transmission). Shortly after starting topamax, my tolerance to caffeine, pseudoephedrine, etc dropped a lot. A lot of speculation I must admit however...
John
> John,
>
> Thanks for the informational reply. You are a good man and I respect your evaluations/opinions. (Your competence is not surprising since most EE's are bright).
>
> Hey, I never heard back from you regarding an exchange you and I began on a thread from last week. Here is a link to my response to you. Please let me know your opinions?
>
> http://www.dr-bob.org/babble/20020322/msgs/99669.html
>
> -- Ron
> ------------------------------------------
> >
> > Hi Ron,
> >
> > I don't know if I really can single out a given medicine. I think it is mainly the combination of Lamictal and Serzone. The topamax may be playing a role too, as it precipitated some hypomania a few months back. The Serzone add on was late in the game and that is when I really got the "dopamine kick". But this is transient with some mood cycling.
> >
> > Best Regards,
> > John
> >
> >
> > > JohnX2,
> > >
> > > You didn't answer Jazzdog's question. Which of your current meds do you believe are improving dopamine transport?
> > >
> > > -- Ron
> > > ------------------------------------
> > >
> > >
> > > > > Is the dopamine from the topamax or the serzone?
> > > >
> > > > I think most of it is from the Big Gulp sitting next to me. ;)
> > > >
> > > > I'm dx BPII. I think I have very old leftover PTSD also.
> > > >
> > > > I get a sustainable AD response from Serzone, but that is it. All the other ADs don't work or make me manic and poop out.
> > > >
> > > > The Topamax was used to help mainly with a facial neuralgia (tension headaches). But it is supposed to be good for PTSD. No "dopamax" for me.
> > > >
> > > > Lamictal does most of the mood chores.
> > > >
> > > > Regards,
> > > > John
poster:JohnX2
thread:100813
URL: http://www.dr-bob.org/babble/20020327/msgs/101120.html