Posted by djmmm on April 21, 2002, at 13:14:52
In reply to seratonin turnover?, posted by geno on April 19, 2002, at 14:39:51
Serotonin turnover involves the entire cycle from mitochondrial synthesis, storage, release, metabolism and diffusion, re-uptake, and metabolism and recycling.
I don't believe Tianeptine atually stimulates the release of serotonin..it does reverse the action of the re-uptake pump, increasing the rate at which serotonin is removed from the synapse, I have heard that Ecstasy (MDMA) uses the re-uptake pump in a similar way, but its actions are different, because MDMA is a substituded amphetamine it releases serotonin, but also acts as a re-uptake inhibitor.
FWIW the closest legal drug to MDMA would be another Phenethylamine like Effexor..but as far as mechanism of action, the legal substituted amphetamine fenfluramine is a serotonin releaser and reuptake inhibitor.
poster:djmmm
thread:103560
URL: http://www.dr-bob.org/babble/20020416/msgs/103718.html