Posted by kregpark@yahoo.com on April 24, 2002, at 12:59:05
In reply to Re: Amisulpride/Sulpiride - nearest US equivalent?, posted by jonh kimble on April 23, 2002, at 14:31:52
My opinion is of course that none of these atypicals is best in those with primary mood disorders.
My personal experience is with amisulpride (3.5 weeks 50mg tapered down to 0), and 1 year prior to that a Dr. gave me sample Zyprexa (I did not ask - and almost threw them away before I did try 1/3 of 1 tablet - 2mg zyprexa) - even that sedated me immediately, I added 150mg Wellbutrin and response (acutely was excellent). Very effective.
I don't think there is any question amisulpride and olanzapine and perhaps some other USA atypicals are effective for negative type symptoms like dysthymia and social withdrawal.
However amisulpride is a benzamide like METECLOPRAMIDE and is not the same category as the USA "atypicals" (some of which do not appear very safe either - but still safer).
I think (and studies suggest) that Zyprexa is probably significantly safer than amisulpride such as amisulpride. And I think it has some similar benefits for dysthymia.
If you take any other drugs concurrently with amisulpride your risk of getting dystonia or dyskinesia will change - SSRI's for example will likely increase your risk.
I think augmenting something that boosts d2 in striatum is a good idea - eldepryl perhaps best for this.
Still - over long term use, affective patients are still highest risk (Parkinson's patients do not take those drugs for example, for obvious reasons - their dopamine being so low). Amisulpride like other antipsychotics also frequently causes Parkinsonism (see METECLOPRAMIDE Parkinsonsism, akathesia, dystonia, dyskinesia, etc).
Thus when you come off of olanzapine after taking it for 6 months or 1 years - then you will be new ground for case studies whether you have developed masked TD or dystonia which became visible on discontinuing the drug.
I do not read a whole lot here, but have noticed that some here mention having EPS - and they have mood disorders. You might query them how their situations got screwed up a bit....
poster:kregpark@yahoo.com
thread:103216
URL: http://www.dr-bob.org/babble/20020416/msgs/103996.html