Posted by 3 Beer Effect on June 5, 2002, at 10:58:19
In reply to Re: ADD Stimulant Prices, posted by nightlight on June 4, 2002, at 22:30:04
I would try to ditch the Dexedrine Spansules and replace them with Dextrostat 10 mg pills 2 to 3x per day. In the prescribing information on their website or in the PDR, they give the blood levels of d-amphetamine (ng/mL) & the IR Dextrostat/Dexedrine are MUCH higher than the Dexedrine Spansules & also MUCH higher than an equal dose of Adderall IR or XR. The Dexedrine Spansules also have a reputation of being erratic.
The D (dextoxatory) isomer of amphetamine is 3 to 4 times more potent for CNS stimulation than the l-isomer. The l-isomer mostly just gives the negative peripheral side effects (1 to 2 more times potent) associated with amphetamines such as increased breathing, heart rate. racemic d,l amphetamine (Benzedrine) was subject to much more abuse back in the late 1960s than Dexedrine ever was. Interestingly enough, Benzedrine is one of the 4 ingredients of Adderall. Dexedrine/Dextrostat only contains the "good" d-isomer.
After reading extensively about the pharmacology of amphetamines Dexedrine/Dextrostat is the clear winner for selective CNS stimulation & on paper is better than Adderall for ADD. I personally think the only redeeming quality about Adderall is that is lasts longer & is available in a wide range of doses, otherwise it just causes more anxiety with less mental stimulation/focus & more anorexia/weight loss (it is really just a discontinued amphetamine diet pill named Obetrol, that they bought & renamed ADDerall).
Dexedrine really screwed up by not offering a wide range of doses. The fact that they only offer a 5 mg pill is absolutely ridiculous. Dexedrine used to be number two to Ritalin, but dropped like a rock after Adderall came out- SmithKline Beecham lost millions cause some moron scientist in charge there didn't come up with 10, 15 & 20 mg tablets, which would have kept it competitive with Adderall.
3 Beers.......
poster:3 Beer Effect
thread:108311
URL: http://www.dr-bob.org/babble/20020602/msgs/108767.html