Posted by Iago Camboa on July 21, 2002, at 8:47:12
In reply to Modafinil vs. Adrafinil, posted by BekkaH on July 20, 2002, at 23:38:44
Yes, the two drugs are chemically very similar and are both members of the same class of pstims.
It's also true that modafinil is an active metabolite of adrafinil but it is not clear the extent (percentage) of the transformation adrafinil > modafinil in the human body. It seems, though, that from an adrafinil initial amount of 300mg (= 1 pill), less (probably much less) than 100mg of modafinil become available to the body for further pstim. action and subsequent degradation. There seems to be no other active metabolite(s) of adraf. and/or modaf. so the two chemicals account for all the observed effects of adrafinil; obviously only modafinil is available
in the Provigil (= modafinil) pills.
The reason only modafinil is available in the US is probably economic: adrafinil is a drug 7 times cheapper than modafinil and there seems to be no economical stimulus for the investment needed to get through the whole process of approval of the drug by FDA.Kind regards,
Iago> Hi. Aren't Modafinil and Adrafinil very similar? Doesn't one of them metabolize into the other? Why is one available in the U.S. but the other is not?
poster:Iago Camboa
thread:113101
URL: http://www.dr-bob.org/babble/20020718/msgs/113143.html