Posted by sleepy lizard on August 11, 2002, at 6:07:17
In reply to Re: remeron, again; help, posted by Nala on August 10, 2002, at 16:48:01
Remeron is unusual in that it will act differently with different doses. At low doses, 15 mg, it blocks mainly the histamine receptors, and that is what causes the sleepiness. At larger doses, 30 mg, it also blocks the NE alpha-2 sites, which is activating, and counters some of the sleepiness. It also blocks 5HTP2a (Serotonin) which gives the AD effects at both doses. There are actually 5 receptor sites that it works on, and three uptake pumps. If you are technically minded, and curious, you can read about it at: http://www.preskorn.com/columns/0003.html
poster:sleepy lizard
thread:115314
URL: http://www.dr-bob.org/babble/20020807/msgs/116026.html